A Parker Project: Immunopathological Characteristics in Patients with Psoriatic Arthritis

Psoriatic arthritis is an autoimmune inflammatory disease sharing common features with both psoriasis and arthritis displaying a wide range of disease manifestations. Patients with psoriatic arthritis represent a heterogenous group that suffer from diverse symptoms, with variations in severity, which respond very differently to available treatment. 

In order to provide precision medicine for patients with PsA, we need to incorporate a thorough investigating of associations between clinical manifestations, patient-reported outcomes and immunopathological mechanisms of responders and non-responders to treatment, contributing to better stratification of patients for future treatment strategies based on patients individual clinical and immunopathological phenotype.

The Parker Institute is a clinical, translational, and epidemiological research facility engaging in research on how to combine information from different fields of research in a big data setting in the search for the missing link between clinical effects of anti-inflammatory treatment and changes in immunocellular mechanisms due to treatment.