Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease

“Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease” describes the concept to generate a molecularly-informed taxonomy of disease as outlined by the National Research Council (US) in 2019. This presentation addresses key challenges that currently hinder the rapid progress towards Precision Medicine in Immune Mediated Inflammatory Diseases and beyond. I aim to provide new concise approaches and examples how biomedical research and clinical diagnostic needs to be refocused to reach this goal and improve ROI in both ways, improving healthcare outcomes and financial success. 

One step is for example the implementation of vertically integrated flagship projects in PPP beyond programs like HORIZON2020 etc. that specifically address a major problem (indication) and that will eventually provide the new tools necessary to generate longitudinal multiomics driven “twins” of human pathologies. In more general terms I will propose the implementation of a new logic and strategy into biomedical and biopharmaceutical R&D that I consider not only essential to fully embrace the opportunities that derive from the convergence of IoT, Artificial Intelligence with Real World Data, multiomics and High Performance Computing, but also crucial to avoid the errors of the past. The overall goal is to describe concise actionable scenarios and a roadmap to eventually deliver Precision Medicine 24/7 around the world.